Targeting the chemokine network in atherosclerosis

Chemokines and their receptors represent a potential target for immunotherapy in chronic inflammation. They comprise large family of cytokines with chemotactic activity, cognate are expressed on all cells the body. This network dictates leukocyte recruitment activation, angiogenesis, cell proliferation maturation. Dysregulation chemokine receptor expression as well function participates many pathologies including cancer, autoimmune diseases In atherosclerosis, lipid-driven inflammation middle-sized arteries, chemokines almost stages disease from initiation fatty streaks to mature atherosclerotic plaque formation. Atherosclerosis its complications main driver mortality morbidity cardiovascular (CVD). Hence, exploring new fields therapeutic targeting atherosclerosis is key importance. review gives an overview recent advances role addresses chemokine-based biomarkers at biochemical, imaging genetic level human studies, highlights clinial trials atherosclerosis.